Polycystic ovary syndrome (PCOS) is a set of symptoms due to elevated androgensin females. Its
Signs include irregular or no menstrual periods, heavy periods, excess body and facial hair, acne,
pelvic pain, difficulty getting pregnant, and patches of thick, darker, velvety skin. It could be a
result from the combination of genetic and environmental factors. Many drugs used for treating this
disease. Several hormones have been measured to evaluate PCOS (progesterone, Estradiol,
Follicular Stimulating Hormone (FSH), Luteinizing hormone (LH), Total Testosterone, Anti-
Mullerian Hormone (AMH), Thyroid Stimulating Hormone (TSH), Prolactin and histopathological
studies. Groups were classified as follow: Group (1) Control, Group (2) Dehydroepiandrosterone
(DHEA only), Group (3) (DHEA and flaxseed), Group (4) (DHEA and alfalfa), Group (5) (DHEA
and Soya), Group (6) (DHEA and Cabergoline), and Group (7) (DHEA and Leuproline). Results:
DHEA in a dose of (1mg/kg) induced PCOS and it was clear by significant elevation of (LH/ FSH
ratio, total testosterone, AMH, TSH, Prolactin) and a significant decrease in progesterone and
estradiol. Leuproline was the best choice to decrease the symptoms of PCOS followed by
cabergoline and the least but still effective were the herbals (Soya, flaxseed, and alfalfa). In
conclusion, DHEA could be used for PCOS induction, Leuproline, cabergoline and phytoestrogen
containing herbals could be used for treating PCOS symptoms. |
