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Ass. Lect. Sara Abd El-Fattah Hassan Madkour :: Theses : |
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| Title | Significance of IMP3 in Dysplasia- Adenocarcinma Sequence in Barrett's Esophagus (Immunohistochemical study) |
| Type | MSc |
| Supervisors | Prof. Dr. Samia ahmed youssef, Ass. Prof. Mohebat Helmy Goda, Dr. Rasha Mahmoud Abd Rabbah |
| Year | 2019 |
| Abstract | Barrett's esophagus (BE) is the replacement of the squamous epithelium of the distal esophagus by a metaplastic columnar epithelium. It has been considered the most important precursor lesion for esophageal adenocarcinoma (EAC) through a series of genetic and epigenetic mutations. The oncofetal protein IMP3 is a member of a family of RNA-binding proteins that promotes tumor cell proliferation, adhesion, and invasion. Aim: The aim of this study was to evaluate IMP3 expression in BE and its associated pathological changes through the malignant progression. Materials and Methods: This retrospective study was done upon 51 different esophageal lesions designated as; 20 cases of EAC and 31 cases of BE. IMP3 immunostaining was done and assessed for each case. Results: IMP3 positivity was seen in 3/11 cases (27.5%) of BE-ND, 6/10 cases (60%) of BE-LGD, 9/10 cases (90%) of BE-HGD, and in all (100%) of EAC cases. IMP3 IHC expression was positively correlated with the different grades of BE (BE-ND, BE-LGD, and BE-HGD) and EAC cases (P |
| Keywords | Barrett's Esophagus, Esophageal Adenocarcinoma, IMP3. |
| University | Benha university |
| Country | Egypt |
| Full Paper | - |
| Title | Assessment of (EZH2) expression, digital image analysis of CD8+ lymphocytes, and Automated nuclear morphometry in renal cell carcinoma |
| Type | PhD |
| Supervisors | Eman M. Zedan; ranih Z. Amer; Marwa S. Abd Allah |
| Year | 2024 |
| Abstract | The enhancer of zeste homolog-2 is overexpressed in many human cancers. High CD8+ T cell density was associated with favorable prognosis in various tumors, but this isn’t true for all cancers. Nuclear grading of RCC is an important prognostic factor but it’s subjective. Automated nuclear morphometry is more accurate. Aim: Evaluation of EZH2 expression, CD8+ density, and nuclear morphometry in RCC. Methods: In this retrospective study, IHC staining of EZH2 and CD8+ was done and assessed for each RCC case. CD8+ density was calculated. Quantitative nuclear morphometry was done by automated image analysis. Results: EZH2 expression showed a highly significant relation with histologic grade(P=0.002), tumor extent(P=0.012), and AJCC stage(P=0.004)& showed a significant relation with nodal metastasis (P=0.033), and distant metastasis(P=0.044). A highly significant relation between CD8+ density and histologic types(P=0.0001), histologic grade(P |
| Keywords | Renal cell carcinoma, EZH2, CD8+, Nuclear morphometry, image analysis |
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| Full Paper | - |
