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Dr. Seham Gouda Amin Hassan Ali :: Publications:

Title:
Association between Q192R polymorphism in the PON1 gene and statin responses in cardiac patients
Authors: Eman R. Abd Elgwada, Eman G. Behirya,∗, Fathy M. Swailemb, Seham G. Ameena, Dalia M. Abdelhasiba, Rabab O. Abd Elhamida
Year: 2018
Keywords: Keywords: PON1 Q192R polymorphism Statin Dyslipidemia
Journal: Annals of Medicine and Surgery
Volume: 31
Issue: Not Available
Pages: 1-5
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Seham Gouda Amin Hassan Ali_Association between Q192R polymorphism in the PON1 gene and statin.pdf
Supplementary materials Not Available
Abstract:

Introduction: Paraoxonases are a group of different forms enzymes that consist of three non-similar isoforms, PON1, PON2 and PON3, which are located near to each other on the long arm of chromosome7. This study aims to investigate the association of a Q192R polymorphism of PON1 gene and statin response in patients with ischemic heart disease with dyslipidemia. Methods: The studied population included three hundred patients with coronary artery disease with dyslipidemia who were prescribed statins. Total lipid profile was measured in these patients both before and after approximately 6 months of treatment. Q192R polymorphism of PON1 gene was assessed by real-time PCR. Results: There were no significant differences in baseline lipid levels according to different genotypes in all studied casesof Q192R (rs662) polymorphism. HDL-C goals were attained less often in patients with RR homozygosity than in Q allele carriers. Analysis by univariate logistic regression confirmed that QQ/QR carriers had an increased chance of attaining HDL-C goals. Conclusion: This study shows that the Q192R polymorphism of PON1gene has important role in interindividual variety in accomplishment of HDL-C goals in response to statins.

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