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Dr. Seham Gouda Amin Hassan Ali :: Publications: |
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| Title: | Telomere length and signal joint T-cell receptor
rearrangement excision circles as biomarkers for
chronological age estimation |
| Authors: | Mostafa Ali Elmadawy , Omnia A. Abdullah , Walaa Bayoumie El Gazzar , Enas Sebaey Ahmad , Seham Gouda Ameen & Afaf Abdelkader |
| Year: | 2021 |
| Keywords: | Chronological age; telomere length; sjTRECs; quantitative real-time PCR; southern blotting |
| Journal: | Biomarkers. |
| Volume: | 26 |
| Issue: | 2 |
| Pages: | 168-173. |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Seham Gouda Amin Hassan Ali_Telomere length and signal joint T cell receptor rearrangement excision circles as biomarkers for chronological age estimation.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Background: Chronological age estimation is a challenging marker in the field of forensic medicine. The current study aimed to investigate the accuracy of signal joint T-cell receptor rearrangement excision circles (sjTRECs) quantification and telomere length measurement as methods for estimating chronological age. Methods: Telomere length was estimated in the DNA derived from the buccal cells through estimating the telomeric restriction fragment (TRF) length using TeloTTAGGG Telomere Length Assay while the sjTRECs quantification was carried out on DNA isolated from the blood samples using qPCR. Results: The TRF length was shortened with increased age (r ¼ 0.722, p |
