Background Enthesopathy is considered a crucial aspect of assessment and outcome in psoriatic arthritis (PsA). Musculoskeletal
ultrasound (MSUS) is a critical tool for accurately detecting enthesitis. Recent research focuses on identifying
simple biomarkers for detecting and monitoring psoriatic enthesopathy. Red cell distribution width (RDW), mean platelet
volume (MPV), and neutrophil/lymphocyte ratio (NLR) are components of a complete blood count (CBC) and are reliable
bio-inflammatory markers in various rheumatic diseases.
Aim of work To measure MPV, RDW, and NLR in psoriatic enthesopathy and determine their relationship to disease activity
and MSUS findings.
Patients and methods This study focused on 30 people with psoriatic arthritis (PsA) as per CASPAR criteria, along with
20 control subjects. Enthesopathy was evaluated clinically using the Leeds Enthesitis Index (LEI). The modified Disease
Activity Index of Psoriatic Arthritis (DAPSA28) was calculated, and RDW, MPV, NLR, CRP, and ESR were measured.
Each enthesis in LEI was radiologically assessed using plain radiography and MSUS according to OMERACT definitions.
Results There was a significant relationship between clinical tenderness, the presence of enthesophytes on plain radiography,
and MSUS findings at entheses sites (p < 0.001 for each). Psoriatic patients had higher levels of RDW and MPV (p < 0.001
and 0.01, respectively) than controls, with no significant differences in NLR (p = 0.189) between the two groups. RDW and
MPV levels were positively correlated with the DAPSA28 score.
Conclusion Monitoring PsA disease activity can be improved by considering RDW and MPV as reliable indicators and using
them to screen for psoriatic enthesopathy with MSUS indices. |
