Background. Genetic predisposition plays a crucial
role in susceptibility to vitiligo. Recent progress is
providing key insights into the manner in which
individual susceptibility genes contribute to disease
pathogenesis and clinical types. T cell and relatedcytokines
have been proved to contribute in vitiligo
pathophysiology.
Objectives. In the present study, we assessed the
association of TNF-α (-308 G/A), IL10 (-1082 A/G)
and FOXP3 (-3279 A/C) genes polymorphisms
among a sample of Egyptian patients with generalized
vitiligo.
Methods. We genotyped 150 unrelated patients with
generalized vitiligo vulgaris and 200 apparently
healthy unrelated control individuals for TNF-α (-308
G/A), IL10 (-1082 A/G) and FOXP3 (-3279 A/C) genes
polymorphisms by ARMS-PCR and PCR-SSP.
Results. We found that AA, GA genotypes and A
allele in TNF-α (G-308A) and GG, AG genotypes and
G allele in IL-10 (G-1082A) polymorphisms were significantly
associated with generalized vitiligo
patients.
Conclusion. Results of the present study suggested
the possible involvement of the TNF-α (-308) A and IL-10 (-1082) G but not FOXP3(-3279 A/C) alleles as a
genetic risk factor for generalized vitiligo among
Egyptian patients. |
