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Prof. Shereen Abd Alfatah Ebrahim Algergawy :: Publications: |
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| Title: | Urinary Angiostatin As Alternative To Biopsy In Lupus Nephritis Patients Among Egyptian.
Algergawy1, Shereen, Alshaar2, Osama, Zakaria3, Rania |
| Authors: | Algergawy1, Shereen, Alshaar2, Osama, Zakaria3, Rania |
| Year: | 2013 |
| Keywords: | Not Available |
| Journal: | Arthritis & Rheumatism, Volume 65, October 2013 Abstract Supplement |
| Volume: | volum 65 |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
Background/Purpose: Lupus nephritis (LN) is one of the most frequent manifestations of SLE and can be present in 60% of SLE patients. Kidney biopsy remains the basis of LN diagnosis. There is urgent need to identify biomarkers that alternative to renal pathology in lupus. Aim: To study urinary angiostatin in SLE and investigate their possible role as indicative of renal involvement to be used as alternative to biopsy. Methods: Angiostatin levels were measured in urine samples from 45 lupus patients and 14 healthy volunteers, renal biopsy was obtained from all patients Results: SLE patients had elevated urinary angiostatin as compared to controls (P < 0.001). Levels of urinary angiostatin were higher in patients with an active LN (lupus nephritis) than those with inactive LN (P < 0.001). In patients with LN urinary angiostatin correlated with the renal score of the Systemic Lupus Erythematosus Disease Activity Index. Urinary angiostatin levels varied significantly and there is significant positive correlation (P |
