Background: Cisplatin (CIS) is a powerful anti-neoplastic medication, it has adverse effects including peripheral neuropathy. Taurine (Tau) protects the cells by stabilizing membranes, regulating calcium levels, antioxidant and modulating apoptosis and inflammation. Objective: evaluate the protective impact of Tau on peripheral neuropathy caused by CIS. Materials and Methods: 45 healthy adult male albino rats spanning 150 to 250 grams were indiscriminately assigned to four groups. Group I: control group. Group II (CIS group): animals were administered intraperitoneal (IP) injection of CIS at a dosage of 2.5 mg/kg/day, with treatments biweekly throughout four-weeks duration Group III (CIS+Tau): Four days prior to the CIS injection, Tau was administered orally by gavage (250 mg/kg/day), Tau then continued for four weeks. Group IV (Tau group): Tau given orally (250 mg/ kg/ day) daily for four weeks. Sciatic nerve samples were obtained and prepared for light and electron microscopy evaluation. Results: Group II showed disorganized nerve bundle architecture and wide separation of nerve fibers. Nuclei of Schwann cells (SC) were small and darkly stained (pyknotic). Inflammatory cell infiltrate was observed. A statically significant difference in collagen fiber deposition (P |
