Lead (Pb) is among the most frequently encountered heavy metals that pollutes the
environment . Lead buildup in body is very common in humans. The general public's
health, particularly children, is also damaged in addition to that of occupationally
exposed persons. Because lead poisoning can impact the body's hematologic, hepatic,
cardiovascular, reproductive, gastrointestinal, and neurological systems, it is known to
alter how the body functions. Pb exposure is connected to atypical social behavior,
alterations in executive function, and cognitive impairment. Pb poisoning is
particularly detrimental to the CNS. Lead's neurotoxic effects may stem from its
capacity to mimic or impede the function of calcium and imbalance between oxidative
stress and antioxidant processes. This review focuses on the lead's detrimental
consequences on the neurological, and hematological systems. It also explains the
neurotoxic mechanisms. The review offers a conceptual framework and future
research paths for lead-induced neurological illness prevention, diagnosis, and
therapy |
