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Dr. Sherif Ibrahim Metwally Ramadan :: Publications: |
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| Title: | Synthesis and Reactivity of 6-Iodo-4H-3, 1-Benzoxazin-4-one Towards Nitrogen Nucleophiles and Their Antimicrobial Activities |
| Authors: | Abdel-Monem MF Eissa, Kouser A Hebash, Mohamed Abo Riya, Sherif IM Ramadan |
| Year: | 2013 |
| Keywords: | Not Available |
| Journal: | Chemical and Process Engineering Research |
| Volume: | 15 |
| Issue: | Not Available |
| Pages: | 18-27 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Sherif Ibrahim Metwally Ramadan_Mohamed Abd El-Rahman Mousa Abu Riya_benzoxazine.pdf |
| Supplementary materials | Not Available |
| Abstract: |
In attempt to find new pharmacological active molecules, we synthesized 6-iodo-4H-3,1-benzoxazin-4-one and allowed it to react with some nitrogen nucleophiles namely; hydroxylamine hydrochloride, hydrazine hydrate, fomamide, aliphatic amine, aromatic amines, aralkyl amine, different amino acids, heteryl amines, ethanolamine and sodium azide to afford annelated quinazolinone derivatives and other related systems. The synthesized compounds were characterized with the help of spectroscopic techniques including IR, 1H-NMR and Mass spectra. Also their antimicrobial activities were screened against different strains of bacteria and fungi. Keywords: 6-Iodo-4H-3,1-benzoxazin-4-one; quinazolinone derivatives; nitrogen nucleophiles; antimicrobial activity . |
