The main objective of this study is to investigate the alterations of resveratrol on oxidative stress in
experimental induced nonalcoholic fatty liver disease (NAFLD) in rats. Thirty male albino rats were
divided into three groups (10 rats each). The first group fed a normal diet and represents the control
group. The second group (NAFLD) fed normal diet enriched with1% cholesterol and 2% coconut oil
and act as positive control. The third group fed on normal diet enriched with1% cholesterol and 2%
coconut oil and Resveratrol at a rat dose3mg/kg body weight / daily /6weeks intra peritoneal (i.p) .
Samples collected after 2, 4 and 6 weeks after treatment. serum was used for estimation of serum nitric
oxid ( NO), L- Malondialdehyde (L-MDA) and Immunoglobulins as serum Immunoglobulin A (IgA)
Immunoglobulin G ( IgG) and liver function tests as serum Aspartate aminotransferase (AST) ,serum
Alanine amino transferase (ALT), serum Gamma glutamyl transferase (GGT). Hepatic tissues for
Enzymatic Antioxidants as Liver Catalase ( Liver CAT),Liver superoxide dismutase(Liver SOD) ,Non
Enzymatic Antioxidants as Liver Reduced Glutathione (Liver GSH). Results revealed a significantly
decrease in serum NO ,Liver CAT, Liver SOD, Liver GSH More ever serum L-MDA, serum AST ,ALT,
GGT were significantly increase concentration In addition to Serum IgA, IgG were also significantly
increase .The behavioral biochemical results indicated treatment with Resveratrol showed a significant
changes and improves these parameters. |
