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Dr. Shuzan Ali Mohammed Ali :: Publications:

Title:
Molecular diagnostic value of pneumococcal pneumonia among Egyptian children
Authors: Ismail Abou El-ela Ramadan, Ahmed Abdel-Rahman El-sharkawy, Mohammed Taki-eldin Elsherbini, Wafaa Elsoody Yehia and Shuzan Ali Mohammed
Year: 2014
Keywords: PCR, autolysin gene, Streptococcal pneumoniae
Journal: International Journal of Development Research
Volume: 4
Issue: 2
Pages: 355-358
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Shuzan Ali Mohammed Ali_1. d Ismail.pdf
Supplementary materials Not Available
Abstract:

Pneumonia is the most common invasive pneumococcal disease; however, only a small portion of cases can be confirmed by conventional techniques. The present study aimed at comparing the molecular detection of Streptococcal pneumoniae by the standard blood culture in communityacquired pneumonia among Egyptian children. Standard blood culture of Streptococcal pneumoniae and sequence-specific PCR amplification of autolysin gene were performed. There was a statistically significant increase in PCR diagnosed cases than that diagnosed by blood culture with higher PCR sensitivity. Also, there was a statistically significant decrease in culture diagnosed cases among those receiving empirical antibiotic treatment prior sampling. This study concluded that molecular detection of Streptococcal pneumoniae may be more accurate and rapid in diagnosis of pediatric community-acquired pneumonia below five years than the standard blood culture.

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