You are in:Home/Publications/Association of bank1 gene polymorphism with type 1 diabetes in a sample of Egyptian children

Dr. Shuzan Ali Mohammed Ali :: Publications:

Title:
Association of bank1 gene polymorphism with type 1 diabetes in a sample of Egyptian children
Authors: Elsayed Amer, Soha Abd El Hady Ibrahim, Ola Galal Ali Behairy, Seham Elsayed Ahmad Ali, Shuzan Ali Mohammed
Year: 2016
Keywords: children, type 1 diabetes, BANK1 polymorphisms, allele discrimination, rs3733197
Journal: International Journal of Current Research
Volume: 8
Issue: 10
Pages: 40005-40009
Publisher: Not Available
Local/International: International
Paper Link:
Full paper Shuzan Ali Mohammed Ali_4. BANK1.pdf
Supplementary materials Not Available
Abstract:

The etiology of human type 1 diabetes is still largely obscure, but it is recognized that both genetic and environmental factors are implicated in its risk. aim: To assess the genetic association of BANK1 rs3733197 polymorphisms in a sample of Egyptian children with T1DM and compare it to healthy controls. methods: We enrolled 100 children;75 children with T1DM and 25 healthy control children matched age and sex Children were subjected to: history taking, clinical examination, measuring fast serum glucose glycosylated hemoglobin (HbA1C), serum total cholesterol and genotyping of BANK1 Alanine383Thereonine SNP (rs3733197) with real- time PCR allele discrimination. results: Patients had statistically significant difference regarding allele frequency of BANK1 (rs3733197) SNP as and it exhibited an increased G allele frequency in diabetic group compared with controls. The alelic association analysis confirmed a significant association with T1DM (OR=2.15, 95% CI = 1.12-4.15), while A allele was decreased in T1DM compared to controls (OR= 0.46, 95% CI= 0.24 -0.89). Only the AA genotype of the additive model in the diabetic group was statistically significant decreased as compared with the control group (p=0.022, OR=0.26 and 95% CI = 0.08-0.86). No statistically significant difference regarding other genotype distribution could be detected. Also, there was no statistically significant association between genotypes and alleles of BANK1 rs3733197 SNP with any of the clinical or laboratory data of the study.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus