Background: Neonatal respiratory distress syndrome (RDS) is a multifactorial disease of preterm influenced by
many factors including gene polymorphism. The aim of the present study was to determine the effect of endothelial
nitric oxide synthase gene glu298asp polymorphism (rs1799983) in developing and grading of RDS in preterm
neonates.
Methods: This study was performed on 65 preterm neonates; 40 with RDS and 25 healthy controls. Genotyping of
endothelial nitric oxide synthase gene glu298asp polymorphism was performed by restriction fragment length
polymorphism.
Results: There were statistical significant increases in TT, (GT+TT) genotypes and T allele frequencies of rs1799983
among RDS neonates compared to controls. As groups were categorized by gestational age; TT genotype and T allele
frequencies were statistically significantly increased in 33-35weeks RDS neonates compared to controls. TT genotype
in RDS was associated with RDS grade III, mechanical ventilation need, and increased mortality. TT genotype, T
allele, gestational age ( |
