You are in:Home/Publications/Genetic polymorphism of interleukin-1 receptor antagonist in Type 1 diabetic children

Dr. Shuzan Ali Mohammed Ali :: Publications:

Title:
Genetic polymorphism of interleukin-1 receptor antagonist in Type 1 diabetic children
Authors: NT Abed, IA Ramadan, SA Mohammed, EM El-Shanawany
Year: 2022
Keywords: key words
Journal: Pediatric Research
Volume: 91
Issue: 6
Pages: 1536-1541
Publisher: Springer Nature
Local/International: International
Paper Link:
Full paper Shuzan Ali Mohammed Ali_Research 3 (April 2021) IL 1 antagonist.pdf
Supplementary materials Not Available
Abstract:

BACKGROUND: Interleukin-1 receptor antagonist (IL1RN) variable number tandem repeats (VNTRs) are not fully understood in Type 1 diabetes mellitus (T1DM). It may affect IL1RN level and modify the disease risk. We aimed to study IL1RN VNTR polymorphism in Egyptian children with T1DM to clarify its potential role as a risk factor for T1DM and its effect on plasma IL1RN level. METHODS: A case-controlled study including 200 children (120 T1DM and 80 controls) was carried on. All children were subjected to genotyping of IL1RN VNTR. Plasma IL1RN was estimated by ELISA. RESULTS: The A1A2 and LS genotypes and A2 allele were significantly higher among cases compared to controls with increased T1DM risk (OR = 5.35, 2.56 and 3.13, respectively). The S allele was significantly elevated in cases compared to controls with 2.09-fold increased risk of having T1DM. The median plasma IL1RN significantly decreased in cases compared to controls. Within cases, IL1RN was significantly decreased in LS versus LL genotype. CONCLUSIONS: There is a strong relationship between IL1RN VNTR and T1DM in Egyptian children. A1A1 genotype, LL genotype, A1 allele, and L allele were protective. A1A2 and LS genotypes, short (S), and A2 alleles were risk factors. IL1RN was decreased in T1DM, especially in LS genotype.

Google ScholarAcdemia.eduResearch GateLinkedinFacebookTwitterGoogle PlusYoutubeWordpressInstagramMendeleyZoteroEvernoteORCIDScopus