Background: Nephrotic syndrome (NS) is a condition characterized by severe proteinuria,
hypoalbuminemia as well as dyslipidemia. The QRS complex represents the electrical depolarization of
the ventricular myocardium. The aim was to assess the presence of fQRS in children with primary NS.
The study also evaluated the relationship between fQRS and myocardial functions.
Methods: This study was a control-sectionalcase-cross study carried out in th Nephrology clinic and e
Cardiology Unit, the period from 2020 to 2022, pediatric department at Benha University Hospital. It
was conducted on fifty children suffering from primary nephrotic syndrome and thirty children
apparently healthy of the same age and sex from the general clinic.
Results: The difference between both groups in conventional echo was not significant except for
LVEDD and ESPAP which were significantly higher in Nephrotic. However, tissue doppler shows that
the left ventricle was more affected on systolic and diastolic functions as (IVR, IVCT, MPI, DT) were
significantly affected in the cases group. While values in the right ventriclewere not significantly
affected. Fragmented FQRS was present in (10%) of patients with tissue doppler values more
significantly affected.
Conclusion: Nephrotic syndrome children generally have a high risk of cardiovascular complications.
FQRS can be used as a marker of myocardial function impairment in this patient group |
