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Advanced Gut & Microbiome Research
Review Article | Open Access
Volume 2023 | Article ID 1080495 | https://doi.org/10.1155/2023/1080495
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Unveiling the Role of Inflammatory Mediators and Gut Microbiome in Appendicitis: Types and Applications in Clinical Scoring
Taher H. Elwan
,1,2Aimen Elsheikh Khalil Abdennour
,1Usama Akl
,1A. T. M. Elshennawy,3and Ibrahim M. Shatla
4,5
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Academic Editor: Jiong Yu
Published10 Jun 2023
Abstract
Appendicitis is a common medical condition that affects millions of people worldwide. It is characterized by inflammation of the appendix. The exact mechanisms that trigger the inflammatory response in appendicitis are not well understood, but it is known that inflammatory mediators play a crucial role in the development and progression of the disease. In this review, we provide a comprehensive overview of the current understanding of the role of inflammatory mediators in the pathogenesis of appendicitis. This review article examines the various types of inflammatory mediators involved, including cytokines, chemokines, and prostaglandins, and discusses their interactions with other cells and molecules in the inflammatory cascade. Our review highlights the complex interplay between inflammatory mediators in the development of appendicitis and their potential implications for diagnosis and treatment of the disease. We discuss the potential for targeted therapies aimed at reducing the production or activity of specific inflammatory mediators, as well as the potential for new diagnostic approaches based on the detection of specific mediators in the blood or other bodily fluids. At the end, the role of inflammatory mediators in appendicitis is an active area of research, and continued investigation is necessary to fully elucidate the mechanisms involved. However, the growing understanding of the complex interactions between these molecules offers new opportunities for the development of targeted therapies and diagnostic tools for this common and potentially serious condition |
