Acetaminophen, a popular nonprescription
analgpsic"-;;;6;;"'il d*g' **, 1d'linistered
oralllt to pregnant "ts 't a dose levels of
o(contro]t): ii, 50, 100, 2oo and 400 mg/kg
body,*"igi,la"y on day'1 to 15 of gestation'
ir,J lOurt were sacrttted on the day 27 of
;;;gr"*y, and. the fetuses were removed by
"r"r.rr.],i',ection
and examined body weight
showed Lvid"n"" of maternal toxicity as exhibited
by marked increase in liver weight and
decreasid boJt weight gain' No. increase in
the incidence of resorptions was observed even
at +oo rngifcg body weight, . a .dose severali-
opt.d"c htiiJgeh-e(ti'O if-,z"on thor" uied in human clinical mg/ks body weight)' . There
rvas "'lo;;-t;lated'
d'""t"*" in fetal body
weights rvhich was statistically significant at
2Oo mg/kt weight or more' Examination of
the r"tu.E, reiealed insignificant increase in
the incia"nce of gross, ikeletal and internal
matformations at Jny dose in comparison with
the controls. However, one of the fetuses in
the gtoup which received 400 mg/kg body
;;ighl shtwed short tail and club foot' Thus'
no evrdlnce of embryocidal and teratogenic
ef f ects was observed with this analgesicantipyretic
drug at the recommended therap"
uiit dose in iats. Acetaminophen should be
tonsidered the safest analgesic-antipyretic
drug during Pregnancy. |
