Background: Uterine leiomyoma represents over 75% of
the amiable tumours in ladies of conceptive age amass.
Endometrium is a hormonally responsive tissue. The
reaction of endometrium to incitement by endogenous or
exogenous steroid hormones is unsurprising endogenous
reaction is an impression of the hypothalamic–pituitaryovarian pathway. Aim of this study: to assess serum level
of E2 and study endometrial histological changes in
instances of fibroid uterus. Patients and methods: This
study included forty ladies have symptomatic fibroid uterus.
history was taken, general examination, ultrasound
examination, measuring serum estradiol and endometrial
biopsy was taken by D&C or hysterectomy sent for
histopathological examination. Results: endometrial
thickness was ˃10mm in 69.2% of premenopausal and
˃5mm in 83%of postmenopausal. endometrial hyperplasia is
the commonest glandular endometrial change represent
(37.5%), complex hyperplasia without atypia 5%, simple
hyperplasia with atypia 5% and proliferative endometrium
22.5%of all review bunch. in premenopausal patients
hyperplasia with atypia related with the most elevated E level ( 252,6 pg) , complex hyperplasia without atypia with
E2 level (221.6 ±6.22 SD), hyperplasia without atypia with E2 level (184.84 ±
12,11SD) and in postmenopausal patients hyperplasia with atypia with E2 level
(245.3 pg), hyperplasia without atypia (145.68 ±33.53 SD) .Conclusion : there is
correlation between serum oestrogen level , histopathological changes of
endometrium and symptomatic fibroid uterus at perimenopausal age .
Key words: Estrogen, Endometrial histology, Fibroid, Peri-menopausal. |
