Objective The ultimate goal of this study is to reassess the five-dimensional implantation markers and pregnancy predictors
on the day of human chorionic gonadotropin injection in the intracytoplasmic sperm injection and embryo transfer programs.
Design A pilot prospective clinical trial.
Setting The Assisted Reproductive Technology Unit of Ain Shams Maternity Teaching Hospital during the period from
April 2014 to December 2017.
Patients and methods The study was conducted on 400 women undergoing intracytoplasmic sperm injection (ICSI). Those
women were not older than 40 years, with normal uterine cavity and with no previous uterine scars.
Intervention The ovarian stimulation protocol, used in this study for all patients, was the long protocol, before ovarian
stimulation therapy, patients were instructed to use oral contraceptive pills from day 2 starting in the preceding cycle, then
the standard regimen. On the day of hCG administration, 5D transvaginal ultrasound measurements were performed by the
same observer after the patients had emptied their bladders. Measurements included endometrial volume and 3D power
Doppler parameters, endometrial vascularization index, flow index, and vascularization flow index.
Results The present study shows that endometrial volume ≥ 5 in the prediction of endometrial receptivity in ICSI patients
had good sensitivity and low specificity in a group application; in an individual application it had good predictive negative
value and bad predictive positive value. So it could be used as a good test to exclude success. Overall pregnancy rate was
40.5%; endometrial volume, flow index, vascularization index, and vascularization flow index were significantly lower in
the nonpregnant group than those of the pregnant group. The area under curve in the receiver operating characteristic for
three-dimensional ultrasound and power Doppler angiography parameters was statistically significant, but their values were
suggestive but not conclusive in the prediction of endometrial receptivity in ICSI patients, no cutoff points with good diagnostic
characteristics could be obtained.
Conclusion Five-dimensional ultrasound and power Doppler angiography is a useful exam to assess the endometrial receptivity
in IVF/ICSI and embryo transfer cycles. |
