This study To evaluate incidence of trichomonas vaginalis infection (TVI), depending on the result of Gen-eXpert TV (GX-TV) assay, among women and its relation to the inci-dence of preterm labor (PTL) among pregnant women and to determine the outcome of two metronidazole (MTZ) therapy regimens on TVI. 468 preg-nant and 217 non-pregnant underwent microbiological workup and graded using Nugent score (NS). Women with NS≥7 received the appropriate thera-py. Group A included responders without recurrence, Group B included women who gave negative GX-TV assay and received 2nd session of treat-ment and Group C included women who gave positive GX-TV assay and received either 1-wk oral MTZ 500 mg twice daily (C1 group) or 1-d single oral MTZ of 2gm (C2 group). Males who gave urine samples positive GX-TV assay received 1-wk MTZ therapy. Group A included 150 women who were responded to treatment without recurrence. The frequency of non-responders among women had NS≥7 was significantly higher among non-pregnant women. GX-TV assay de-fined 204 negative samples (Group B) and 331 positive sample with signifi-cantly higher frequency of positive samples compared to microscopic ex-am and traditional culture. In com-parison to GX-TV assay, both micro-scopic examination and traditional culture showed missed diagnosis of 43-59% of cases. At 3-m and 6-m follow-up, recurrence rate (RR) of TVI was significantly higher in C2 than C1 group especially in non-pregnant with significantly higher RR at 6-m than at 3-m. Only 234 males undertook TV testing and 187 males gave positive urine samples. PTL rate was 9.1% and was significantly higher in women had recurrent TVI and in women of C2 than C1 group. this study revealed that Vaginitis had high prevalence among pregnant and non-pregnant women and high percentage of non-responders to treatment had TVI. Screening for TVI using GX-TV assay allows rapid and accurate identifica-tion of TVI with high sensitivity and specificity. MTZ treatment allows in-fection eradication but had 21% RR within 6-m especially with 1-d regi-men. PTL rate was high with TVI es-pecially if recurrent. Male partner
SCREENING OF WOMEN FOR TRICHOMONIASIS USING GENEXPERT PLATFORM ASSAY ALLOWS EARLY TREATMENT AIMING TO REDUCE THE INCIDENCE OF PRETERM LABOR AMONG PREGNANT WOMEN
By
Youssef M Abdel Zaher, Marwa M Nageeb*, Ibrahiem M Rageh**
Departments of Obstetrics & Gynecology, Medical Parasitology* and Clinical
Pathology**, Faculty of Medicine, Benha University, Egypt
THE EGYPTIAN JOURNAL OF MEDICAL SCIENCES VOL. 40-No. 2 – DECEMBER 2019 (ISSN: 1110-0540)
1. Egypt. J. Med. Sci. 40 (2) December 2019: 527-546. http://www.ejmsonline.org/abstracts/1093
must be screened and treated to pre-vent female re-infection. |
