The present study was planned to determine the effect of some familiar drugs used for dog treatment
including antibiotic as E-Mox®; antiparasitic drugs as levamisol® and Yomesan® on the immune
response of dogs to the locally produced inactivated rabies vaccine, through the application of SNT and
indirect solid phase ELISA. SNT revealed that specific rabies neutralizing antibodies stated from the
first week post vaccination in vaccinated all puppy groups then increased gradually to reach their peak
by the 4th week later then still unchanged till the 12th month. It was visible that the highest levels of
serum neutralizing rabies antibodies were determined in puppies received Levamisol® reached 256.
Other treated puppy groups did not show significant differences between them. The vaccinated untreated
group and Yomesan® treated group were reached 32 meanwhile the treated group with E-Mox®
which showed the lowest antibody titer was 16. It was clear that the results of ELISA were in parallel
to those of SNT showing that the highest levels of rabies ELISA antibodies were determined in puppies
received Levamisol®. Other treated groups did not show significant differences. The results of the
vaccinated un-treated group and Yomesan® treated group were similar. While the treated group with
E-Mox® showed the lowest antibody titer. Similarly, the serum proteins showed elevation in the
Levamisol® treated group. On the other hand the E-Mox® treated group showed the lowest serum
proteins level. There were no significance differences the level of the serum protein among the other
groups. |
