The goal of this research was to determine the effect of different doses of mannanoligosaccharide (Bio-Mos®) prebiotic feed additives as a growth promoter on the antioxidant enzyme activities, level of lipid peroxidation and extent of DNA damage in Japanese quail chicks. Sixty Japanese quail chicks were randomly divided into four groups with 15 chicks in each group. The first group was considered as control group and fed the basal diet only while the prebiotic Bio-Mos® was added to combined feed of the 2nd ,3rd and 4th group of chicks at a rate of 0.5, 1, 2 g/kg basal diet, respectively. At the end of the experimental period, that is, after 56 days, chicks were killed. The results presented in the current study revealed that Bio-Mos® is a beneficial dietary supplement for improving antioxidant activities and decreasing lipid peroxidation level. Also, Bio-Mos® has a positive impact on the extent of DNA damage in blood cells estimating by comet assay and RAPD-PCR with decrement of fragmented DNA level in hepatocytes of quail chicks. The study suggested that Bio-Mos® can be used in practice as a dietary additive for Japanese quail, stimulating the mechanisms of the birds’ antioxidation defense and preventing DNA damage. |
