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Dr. Bahaa El-Dien M. El-Gendy :: Publications: |
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| Title: | Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines |
| Authors: | Ebrahim H. Ghazvini Zadeh, Bahaa El-Dien M. El-Gendy, Alex G. Pop and Alan R. Katritzky |
| Year: | 2012 |
| Keywords: | Not Available |
| Journal: | Not Available |
| Volume: | Not Available |
| Issue: | Not Available |
| Pages: | Not Available |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | |
| Full paper | Not Available |
| Supplementary materials | Not Available |
| Abstract: |
Enantiopure N-(Cbz, Fmoc, Boc, or Ac)-1H-1,2,4-triazole- (8a–p, and 8f′) and previously unknown N-Cbz-1,2,4-triazine-derived α-amino acids (11a–d, 11d′, 13a,b, and 13a′) were synthesized using microwave irradiation. Reaction conditions led unexpectedly to simultaneous cyclization, deprotection and acetylation of N-Boc-aminoacylamidrazones 7m,n to afford N-acetyl-1H-1,2,4-triazoles 8o,p. |
