You are in:Home/Publications/α-Substitution Effects on the Ease of S→N-Acyl Transfer in Aminothioesters | |
Dr. Bahaa El-Dien M. El-Gendy :: Publications: |
Title: | α-Substitution Effects on the Ease of S→N-Acyl Transfer in Aminothioesters
|
Authors: | Bahaa El-Dien M. El-Gendy, Ebrahim H. Ghazvini Zadeh, Ania C. Sotuyo, Girinath G. Pillai andAlan R. Katritzky |
Year: | 2013 |
Keywords: | Not Available |
Journal: | Not Available |
Volume: | Not Available |
Issue: | Not Available |
Pages: | Not Available |
Publisher: | Not Available |
Local/International: | International |
Paper Link: | |
Full paper | Not Available |
Supplementary materials | Not Available |
Abstract: |
In S-acylcysteines and homocysteines, the efficacy and rate of S→N-acyl transfer (5 and 6 cyclic TSs) vary with the size of S-acyl group. Conformational and quantum chemical calculations indicate that the spatial distance, b(N-C), between the terminal amine and the thioester carbon is shortened by α-C(O)X (X = OH, OMe, NH2) substituents. |