Hepatitis C virus infection played the major role in the causation of chronic liver disease in Egypt. Schistosomal patients are considered a high-risk people contributing to hepatitis B, C infection or both. The outcome of hepatitis C virus infection is known to be highly variable and restricted by the products encoded by the major histocompatibility (MHC). The principle reasons for discrepancies in the HLA typing results are likely to be disease heterogeneity, racial differences in the distribution of HLA alleles between populations, and in some cases, low number of patients studied. Our present study was carried out on 30 healthy anti-HCV-negative controls, 30 cases of CPH and 3 cases of CAH diagnosed by the presence of HCVRNA by RT-PCR and liver biopsy detect chronic active and chronic persistent hepatitis. The collected samples were analyzed for LFT, CBC, serum iron, AFP, HLA class I & II. The obtained results were analyzed statistically and discussed briefly. HLA-DR2 antigen was found to be frequently present in patients with CPH, while HLA-DR3 antigen was found frequently present in patients with CAH. |
