Objectives: to detect prevalence of subclinical hypothyroidism (SCH) among acute coronary syndrome patients and to assess its association with both inhospital morbidity and mortality.
Methods: The study included 300 patients admitted with the diagnosis of acute coronary syndrome (either STEMI or NSTEMI or UA) with close follow up during the inhospital stay to detect any morbidity or mortality. All subjects underwent complete lipid profile (TC-TG-LDL-C-HDL-C-VLDL-C) and thyroid profile (free T3-free T4-TSH).
Results: SCH was associated with hypercholesterolemia (in 83.1% of patients), hypertriglyceridemia (in 80% of patients), increased LDL-C (in 83.3% of patients), decreased HDL-C (in 85.7% of patients) and increased VLDL-C (in 86.6% of patients). The prevalence of SCH among ACS patients was 5%. Morbidity was 34.6% in ACS patients with normal thyroid profile (euthyroid) vs. 20% in those with SCH (p value 0.7). Mortality was 2.5% in ACS patients with normal thyroid profile (euthyroid) vs. 0% in those with SCH (p value more than 0.05).
Conclusion: Prevalence of SCH is 5% in ACS patients and it has no association with inhospital morbidity and mortality. |
