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Dr. Ola Samir Ahmed El-Shimi :: Publications: |
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| Title: | ASSOCIATION OF E-SELECTIN GENE POLYMORPHISMS IN EGYPTIANS WITH CORONARY ARTERY DISEASE |
| Authors: | Heba Mosaad, Mohamad Motawea, Ahmed El Said, Ola El-Shimi |
| Year: | 2016 |
| Keywords: | E-selectin, polymorphism, PCR-RFLP, CAD, Egyptians. |
| Journal: | EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH (ejpmr) |
| Volume: | 3 |
| Issue: | 7 |
| Pages: | 53-58 |
| Publisher: | Not Available |
| Local/International: | International |
| Paper Link: | Not Available |
| Full paper | Ola Samir Ahmed El-Shimi_Puplished Full article.pdf |
| Supplementary materials | Not Available |
| Abstract: |
Genetic polymorphisms of the E-selectin are associated with coronary artery disease. Objectives: We aimed to investigate the association between the A561C and G98T polymorphisms in E-selectin gene and coronary artery disease in Egyptian population. Subjects & methods: The study enrolled 251 individuals, classified into 2 groups: 152 coronary artery disease patients and 99 normal healthy individuals. A561C and G98T polymorphisms of E-selectin were analyzed by PCR-RFLP (Polymerase chain reaction - Restriction fragment length polymorphism) technique. Results: The frequency of C allele of the E selectin A561C polymorphism was higher in coronary artery disease patients than control group but with no statistical significant difference between the two studied groups (p=0.53). The frequency of T allele of G98T polymorphism of E-selectin was higher in coronary artery disease patients when compared to control group but with no statistical significant difference (P=0.36). Conclusion: A561C and G98T polymorphisms of E-selectin gene are not associated with the predisposition to coronary artery disease and appear to be protective in Egyptian population. |
