The present study was conducted to explore the influence of water pollution on the efficiency of vaccination program. Samples of drinking water offered to sheep were collected where the concentrations of some pollutants were estimated. The results indicated pronounced high levels of nitrate and copper in water. These results were encouraging to investigate the effect of these toxicants on immune response of sheep vaccinated with bivalent lamb dysentery and pulpy kidney vaccines. Four equal groups of sheep were used in this experiment. These groups were offered drinking water containing sodium nitrate or copper sulphate or combination of sodium nitrate and copper sulphate in the first three treated groups respectively and the fourth group was kept as a control. The effect of these pollutants on total, differential leukocytic count and some serum parameters were recorded. Also body weight gain and clinical manifestations were observed. The result of this investigations revealed that these chemicals suppressed the immune response of vaccinated sheep where unprotective level of Epsilon antitoxin titre was found in treated groups
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