Gene Expression Of 5-lipoxygenase And Lta4 Hydrolase In Children With Nephrotic Syndrome:

Mohamed Abd El Hamid Tawfik

-There is up regulation of gene expression of both 5-LO and LTA4 hydrolase in active PNS patients. So, 5-LO and LTA4 hydrolase expression may participate in the pathogensis and activity of PNS directing our attention for using specific enzyme inhibitors for 5-LO pathway as an adjuvant model of theraphy in these patients.-As our study showed that there was nosignifncant difference in the expression of 5-LO LTA, hydrolase between steroid sensitive &steroid resistant patient. So, expression of both enzyme cant be used as a marker for steroid sensitivity.-There was no significant difference etween different clinical types of SSNS or between different pathological types of SRNS.