Ealuation Of Possible Role Of E-cadherin Catenin Complex As A Marker Of Invasive Bladder Carcinomas:

Adel Hamdy El-sadawy

Carcinoma of the urinary bladder is second most conunonnalignancy. It has a well defined etiology, natural history, treatment Ttions and outcome.E-cadherin-catenin complex is the prime mediator of intercellular dhesion in epithelial cells. Down regulation of E-cadherin-catenin mnplex was reported to be directly related to the invasiveness and .ognosis of many human epithelial tumor types including bladder cancer.This work aims at detection of the importance of E-cadherin-cateninmplex in cases of bladder cancer as regards the invasiveness of the nor.This study was carried out on forty radical cystectomy specimens In 40 patients with muscle-invasive bladder cancer, during the period n April 2000 till December 2003, diagnosed at the pathology artment, Tanta Cancer Institute. Rediagnosis of which wasopathologically confirmed. For each patient, the following clinical data e recorded:1-Age.2-Gender.3-Clinical stage.4-Presence or absence of distant metastasis.5-Survival (living or dead).