Effect Of Oral Contraceptive Pills Genera On Serum Lipid Profile:

Mohammed Salah Moselhy Mosallam

The present work investigates the effects of the newformula oc pills EE./gestoden on lipid metabolism.The study was conducted at Benha University Hospitals,during the period from July 1992 to January 1993. 50 fertilehealthy women participated in this work. All cases fulfilledthe selective criteria. All cases were subjected for enoughclinical history and complete examination, Fasting bloodsamples were taken and estimation of total cholesterol,triglycerides, LDL-c and HDL-c were done before pill intakeand 6 months after.The present work showed :1) No statistically significant changes in total cholesterollevel 6 months after pills intake.2) There was a statistically significant increase in triglycerideslevel 6 months after pills intake (P <0.01).3) No statistically significant changes in LDL-c level 6months after pills intake.4) No statistically significant changes in HDL-c level 6months after pills intake.5) No statistically significant changes in LDL-c/HDL-C ratio6 months after pills intake.6) LDL-C/HDL-C ratio was less than 3 after 6 months of pillsintake, so there is no atherogenic risk factor of usage of the pills, because the ratio did not exceeded the normalrange.it is concluded that, gynera pills over the time period,exert a very minimal change, in the lipid profiles. Thechanges which did occur, would suggest that gestoden, is nota strong anti-estrogenic as gestogens used in many existingOCs. The minimal effect on lipid profiles, makes gynera pillsan ideal alternative to existing formulation.