Study Of Some Phagocytic Aspects Of The Polymorphau Clear Leucocytes In Iron Deficient Children:

Osama Abd El Raof Aly

This study about phagocytosis in iron deficient children, was done upon two groups of children :1st group :”9” children with clear cut iron deficiency anemia, other vitamin and nutrient deficiency were eluded through laboratory and clinical parameters.2nd group :5 healthy children used as control group. Experimental work of their study comprised two clinical laboratory methods for assessment of phagocytosis, namely :(I) N.B.T. day reduction test :is a test for assessment of intercellular killing by P.M.N, statistical analysis of results in both disease and control groups show marked decrease in N.B.T dye reduction by granulocytes of diseased group versues control group.(2) Neutrophil microbricidel assay using candida olbicons.Results were correlated with N.B.T. dye reduction test, where statistical analysis show significant decrease in power of neutrophils for englufing and killing of candida olbicans in diseased group versues control group.We can conclude that there is an intimate relation between iron depletion from tissues (as indicated by low Hb concentration). And a defect in the natural immunity of the host, mainly phogocytic power of the neutrophillic granulocytes. This defect is manifested as a reducation in both N.B.T. test and phagocytosis of candida abicans by PMNs over a brief period of time.