Study On Primary Antiphospholipid Syndrome As An Independent Risk Factor For Cerebral Ischemia:

Ahmed Hamdy Gamal El-din Ahmed

Antiphospholipid antibodies ( APAs), namely , lupus anticoaglant & anticardiolipin antibodies are acquired autoantibodies that can occur in many pathological conditions as connective tissue diseases ( S.L.E & Rheumatoid arthritis) & in infectious disease (acquired immunodeficieny syndrome , infectious mononucleosis & in chronicinfections as leprosy ) as well as drug induced ( Fansidar , Hydralizine , Streptomycin , Quindine , Procainamide ) .Patients with APAs are prone to repeated episodes of both arterial &Venous thrombosis , Cardiomyopathy , thrombocytopenia , Fetal losses , renal failure , neurological & Skin manifestations .The primary antiphospholipid antibodies syndrome refers to thepresence of the above dinical manifestations without evidence of an associated autoimmune disorders .conducted on 50 patients with cerebral ischemia ( Cerebral thrombosis ,transient ischemic attacks ) as well as 15 healthy controls , patients were classified into 2 groups :- Group 1 :It included 30 patients ( 10 males & risk factor that can predispose to D.M , hyperlipoproteinemia .. etc ..The aim of our work is to shed light on the prevelance of APAs & the role played by these antibodies in cerebral ischemia . Our study was20 females ) with no evidence of any cerebral ischemia e.g hypertension ,